Non-monotonic temperature dependent transport in graphene grown by Chemical Vapor Deposition

Temperature-dependent resistivity of graphene grown by chemical vapor deposition (CVD) is investigated. We observe in low mobility CVD graphene device a strong insulating behavior at low temperatures and a metallic behavior at high temperatures manifesting a non-monotonic in the temperature dependent resistivity.This feature is strongly affected by carrier density modulation. To understand this anomalous temperature dependence, we introduce thermal activation of charge carriers in electron-hole puddles induced by randomly distributed charged impurities. Observed temperature evolution of resistivity is then understood from the competition among thermal activation of charge carriers, temperature-dependent screening and phonon scattering effects. Our results imply that the transport property of transferred CVD-grown graphene is strongly influenced by the details of the environmentComment: 7 pages, 3 figure

Tonicity response element binding protein associated with neuronal cell death in the experimental diabetic retinopathy

AIM: To study the contribution of tonicity response element binding protein (TonEBP) in retinal ganglion cell (RGC) death of diabetic retinopathy (DR). METHODS: Diabetes was induced in C57BL/6 mice by five consecutive intraperitoneal injections of 55 mg/kg streptozotocin (STZ). Control mice received vehicle (phosphate -buffered saline). All mice were killed 2mo after injections, and the extent of cell death and the protein expression levels of TonEBP and aldose reductase (AR) were examined. RESULTS: The TonEBP and AR protein levels and the death of RGC were significantly increased in the retinas of diabetic mice compared with controls 2mo after the induction of diabetes. Terminal deoxynucleotidyl transferase (TdT) -mediated dUTP nick end labeling (TUNEL) -positive signals co -localized with TonEBP immunoreactive RGC. These changes were increased in the diabetic retinas compared with controls. CONCLUSION: The present data show that AR and TonEBP are upregulated in the DR and TonEBP may contribute to apoptosis of RGC in the DR.close2

Reliability-Resiliency-Vulnerability approach for drought analysis in South Korea using 28 GCMs

This study developed a Reliability-Resiliency-Vulnerability (R-R-V) approach that aggregates the frequency, duration, and severity of droughts estimated using the Standardized Precipitation Evapotranspiration Index (SPEI). This approach was used to analyze the characteristics of droughts for the current (1976-2005) and the future (2010-2099) climates. The future climate data obtained from 28 general circulation models (GCMs) of Coupled Model Intercomparison Project Phase 5 (CMIP5) was divided into three general periods: Future 1: 2010-2039, Future 2: 2040-2069; and Future 3: 2070-2099. As a result, aggregation R-R-V representing water availability would increase during Future 1, and then gradually decrease until the end of the century. The frequencies of future drought events for Future 2 and Future 3 were similar to the current frequency, while the durations will be longer and the severity will be higher at most locations during Future 3. Thus, the mean of R-R-V over South Korea is expected to decrease, except for Future 1, and the spatial variability of R-R-V is expected to increase. In the end, the changes in the mean and variance of rainfall and temperature would lead to a decrease in the mean and increase in the spatial variation of sustainability in South Korea. This approach and its results can be used to establish a long-term drought strategy for regions where the risk of future drought is expected to increase

Could Fractional Exhaled Nitric Oxide Test be Useful in Predicting Inhaled Corticosteroid Responsiveness in Chronic Cough? A Systematic Review

© 2016 Background Fractional exhaled nitric oxide (FENO) is a safe and convenient test for assessing T H 2 airway inflammation, which is potentially useful in the management of patients with chronic cough. Objective To summarize the current evidence on the diagnostic usefulness of FENO for predicting inhaled corticosteroid (ICS) responsiveness in patients with chronic cough. Methods A systematic literature review was conducted to identify articles published in peer-reviewed journals up to February 2015, without language restriction. We included studies that reported the usefulness of FENO (index test) for predicting ICS responsiveness (reference standard) in patients with chronic cough (target condition). The data were extracted to construct a 2 × 2 accuracy table. Study quality was assessed with Quality Assessment of Diagnostic Accuracy Studies 2. Results We identified 5 original studies (2 prospective and 3 retrospective studies). We identified considerable heterogeneities in study design and outcome definitions, and thus were unable to perform a meta-analysis. The proportion of ICS responders ranged from 44% to 59%. Sensitivity and specificity ranged from 53% to 90%, and from 63% to 97%, respectively. The reported area under the curve ranged from abou t 0.60 to 0.87; however, studies with a prospective design and a lower prevalence of asthma had lower area under the curve values. None measured placebo effects or objective cough frequency. Conclusions We did not find strong evidence to support the use of FENO tests for predicting ICS responsiveness in chronic cough. Further studies need to have a randomized, placebo-controlled design, and should use validated measurement tools for cough. Standardization would facilitate the development of clinical evidence

Electrically Evoked Cortical Potentials (EECP) in Rabbits Using Implantable Retinal Stimulation System

NBS-ERC Supported by KOSEF (Grant R11-2000-075-01001-0) & Korea Health 21 R&D Project MOHW A05025

Long-Term Reliability of Polyimide Electrode Array in Rabbit Retina

Korea Health 21 R&D Project MOHW A050251, NBS-ERC supported by KOSE

Uncertainty in rainfall intensity duration frequency curves of Peninsular Malaysia under changing climate scenarios

This study developed a methodological framework to update the rainfall intensity-duration-frequency (IDF) curves under climate change scenarios. A model output statistics (MOS) method is used to downscale the daily rainfall of general circulation models (GCMs), and an artificial neural network (ANN) is employed for the disaggregation of projected daily rainfall to hourly maximum rainfall, which is then used for the development of IDF curves. Finally, the 1st quartiles, medians, and 3rd quartiles of projected rainfall intensities are estimated for developing IDF curves with uncertainty level. Eight GCM simulations under two radiative concentration pathways (RCP) scenarios, namely, RCP 4.5 and RCP 8.5, are used in the proposed framework for the projection of IDF curves with related uncertainties for peninsular Malaysia. The projection of rainfall revealed an increase in the annual average rainfall throughout the present century. The comparison of the projected IDF curves for the period 2006-2099 with that obtained using GCM hindcasts for the based period (1971-2005) revealed an increase in rainfall intensity for shorter durations and a decrease for longer durations. The uncertainty in rainfall intensity for different return periods for shorter duration is found to be 2 to 6 times more compared to longer duration rainfall, which indicates that a large increase in rainfall intensity for short durations projected by GCMs is highly uncertain for peninsular Malaysia. The IDF curves developed in this study can be used for the planning of climate resilient urban water storm water management infrastructure in Peninsular Malaysia

Cough persistence in adults with chronic cough: a 4-year retrospective cohort study

BackgroundThere is very limited evidence regarding long-term prognosis of chronic cough. We examined longitudinal outcomes among patients with chronic cough, and explored predictors of cough persistence.MethodsA retrospective cohort was constructed of adults who had newly visited a specialist cough clinic in 2012–2013. All had undergone systematic investigation for chronic cough. The Hull Airway Reflux Questionnaire (HARQ) was administered to assess reflux cough symptoms. A follow-up survey was conducted in 2016–2017 to assess cough persistence.ResultsFrom 418 candidates, 323 participated in the follow-up study; main analyses focused on patients with chronic persistent cough (n=64; 19.8%) and remitted cough (n=193; 59.8%). Compared with remitted cough, chronic persistent cough group had more family history of chronic cough (17.2% vs. 4.7%, p=0.001) and cold air-sensitive cough (62.5% vs. 44.6%, p=0.013). The total HARQ score did not differ; however, two items (cough with eating and cough with certain foods) scored significantly higher in chronic persistent cough. In multivariate analyses, a family history of chronic cough (adjusted odds ratio 4.27 [95% confidence interval 1.35-9.89]), cold air-sensitive cough (2.01 [1.09-3.73]), and cough with eating (1.22 [1.02–1.45]) were associated with chronic persistent cough at 4 years.Conclusions Cough persists in about 20% of patients after 4 years following systematic assessment and treatments. Several cough characteristics, such as family history, cold air-sensitivity, or reflux cough, may be associated with cough persistence. Larger cohort studies are warranted to further understand long-term prognosis and confirm predictors of persistence in patients with chronic cough